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ALSA-Initiated Scientific Research

This aggressive, ALS cure-directed research effort, launched in May 2000 by The ALS Association, seeks answers to key questions that must be addressed in order for better treatments and ultimately a cure for ALS to be found. This research effort complements and works in tandem with The ALS Association's Investigator-Initiated research program.

Focus of these projects includes, but is not limited to the following areas of promise:

 

View ALSA's
Research Portfolio

 

  • Human genetics - Identifying new genes involved in familial ALS
  • Genomics - Using information from the DNA sequence of the human genome to aid in genetic studies, and to search for the expression of genes associated with the disease
  • Animal Models: Transgenic mice, transgenic rats and Drosophila (fruit flies)
  • Assay development and high throughput drug screening
  • Stem cell research as potential for replacing dying neurons
  • Providing important trophic factors to dying cells and Gene Therapy and Diagnostic Biomarkers

Studies Initiated in 2005

ALS model development sensitized screens for genetic modifiers of ALS in mice
Combined delivery of growth factors and astrocytes as a potential treatment for ALS
Function of in vitro produced human motor neurons
Reduction of Oxidative Stress in ALS Subjects with R(+) Pramipexole Treatment
Suppression of SOD1 as a therapy for familial ALS
Identification of Diagnostic Biomarkers and Therapeutic Targets for ALS
Nogo and Nogo Receptor in Transgenic ALS

Studies Initiated in 2004

ALS Model Development: Sensitized Screens for Genetic Modifiers of ALS in Mice
Generation of Transgenic Zebrafish Carrying Mutations in the Zebrafish SOD1 Gene
Long-term Toxicity and Expression of CERE-130 (AAV-IGF-1) Following Intramuscular Delivery in Rodents
Studies of Fv Single Chain Antibodies and Peptides in FALS
C. elegans Model System for Expression of Mutant SOD1 (Renewal)
NOGO and NOGO Receptor in Transgenic ALS (Renewal)
Implantation of HB9 GFP Genetically Engineered Mouse Embryonic Stem (ES) Cells to Restore Function in a Rat Model of ALS (Renewal)
Identification of Diagnostic Biomarkers and Therapeutic Targets for ALS
Purification and Transplantation of Human Stem Cell Derived Motoneurons
RNAi-Based Approach to Understanding and Treatment of ALS
Targets for ALS
Treatment of Familial Amyotrophic Lateral Sclerosis
Screens for ALS Therapeutics

Studies Initiated in 2003

C.elegans Model System for Expression of Mutant SOD1
Characterization of Neurotrophic Factor Receptor Expression in Motor Neurons
Clinical trial of Insulin-like Growth Factor-1 (IGF-1) in Amyotrophic Lateral Sclerosis
Development of Animal Models for Studying The Role of Nitric Oxide in ALS
NOGO and NOGO Receptor in Transgenic ALS
Pilot Study to Screen FDA-approved Compounds in the SOD1 Mouse Model
Role of IGF-1 in Preventing Neurodegeneration in an IGF-1/SOD1 Hybrid Model of ALS

Studies Initiated in 2002

Autoimmunity and the Pathogenesis of Amyotrophic Lateral Sclerosis (ALS)
Development of Knock-in Mice Expressing Mutant G86R SOD1 in a Cell and Tissue Specific Manner
Implantation of HB9 GFP genetically engineered mouse embryonic stem (ES) cells to restore function in a rat model of ALS
New Genetic Model of ALS
Stem Cell Therapy for ALS
Supplement Funding for Distribution of G93A Rat Model
Treatment of Familial Amyotrophic Lateral Sclerosis

Studies Initiated in 2001

Development of a Transgenic Mouse Model with Muscle-Specific Expression of G93A SOD1
Generation and Characterization of an Inducible model of ALS
Generation of ALS2CR6 Knockout Mice
Generation of Human Motor Neurons from Stem Cells

Studies Initiated in 2000

Assay Development
Detection, Development and Characterization of New Mouse Models for ALS
Role of Apoptosis Inducers and Downstream Pathways in Mutant SOD1-related Motor Neuron Degeneration




 ALS Research Overview
Read The ALS Association's White Paper on the State of ALS Research.
 TREAT ALS
Read about the new initiative to accelerate clinical trials through ALS Research.
 Meet The ALS Association's  Chief Scientist
Read interviews with Science Director Lucie Bruijn, PhD.
>> 2004 interview
>> 2006 interview
 Research Grants
Send us an email with your contact information if you would like to be added to our abstract call list.



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