The ALS Association
Ice Bucket Challenge Progress

YOU can make an impact: Project MinE

Thank you for your interest in helping to sequence the genes of 15,000 people living with ALS and 7,500 healthy participants. Project MinE is an international, large-scale research initiative devoted to discovering genetic causes of ALS and to ultimately find a cure.

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Project MinE principle investigators: Jonathan Glass, M.D. at Emory University in Atlanta; and John Landers, Ph.D. at University of Massachusetts Medical School in Worcester, Mass.

Jonathan Glass, M.D. and John Landers, Ph.D.

Bernard Muller and Robbert Jan Stuit, both entrepreneurs and people living with ALS, teamed up to change the genetic landscape of ALS and founded this initiative. Immediately following the ALS Ice Bucket Challenge, The ALS Association announced a commitment of $1 million to fund the U.S. arm of the initiative.

Project MinE is based on the fact that genes are thought to contribute, directly or indirectly, to most cases of ALS. Many ALS genes have been identified, but researchers suspect that many additional, much rarer, variants that affect the risk of ALS, are still awaiting discovery.

Discovering new genes will allow these genes to be placed into ALS disease pathways that could potentially be targeted for ALS therapeutics.

Project MinE has recently identified two new genes – NEK1 and C21orf2 – discoveries that were published in July 2016 in back-to-back articles in Nature Genetics. The discovery of NEK1 would not have been possible without ALS Ice Bucket Challenge funding from The ALS Association.

As of September 2016, Project MinE has achieved 35 percent of its goal, sequencing a total of 7,861 DNA profiles out of the 22,500 goal. But there is much more left to be done and sequencing just one person’s DNA costs $2,000.

Your support is urgently needed so please consider making a donation to support Project MinE today. To learn more about this opportunity to give, please contact us.

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