A Randomized Crossover Study of standard NIPPV and low expiratory pressure NIPPV in ALS patients

University of Michigan, Department of Neurology

Hypothesis:
The purpose of the study is to test whether NIPPV without EPAP (IPAP-only) will result in an increase in patient usage of NIPPV compared with standard NIPPV. Secondarily, we will assess measures of dyspnea, quality of life, patient satisfaction, and side effects. IPAP-only NIPPV represents a novel method of administering NIPPV in ALS patients. The results of this study will directly impact clinical care by identifying which NIPPV technique (standard vs IPAP-only) improves NIPPV use. An increase in NIPPV use may result in improved survival and quality of life in patients with ALS. Secondly, the results of this study will inform future clinical studies directed at NIPPV treatment in the ALS population.

Aim:
To conduct a randomized, crossover study comparing standard NIPPV with IPAP-only NIPPV, with respect to objective NIPPV use, quality of life, patient satisfaction, and side effects. IPAP-only NIPPV will use the same pressure support as standard NIPPV but will have an EPAP equal to zero.

Status:
Patients will be recruited from the University of Michigan Motor Neuron Disease clinic.