The ALS Association
ALS Ice Bucket Challenge Progress

Advancing ALS Research

The world is our lab.

With your support, The ALS Association’s research program fuels global collaboration to expedite the discovery of treatments and a cure for amyotrophic lateral sclerosis (ALS).

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FAQs: 2020 Research & COVID-19

The ALS Association is working urgently to develop effective treatments for ALS. At the same time, we, and the scientists we are funding around the world, are impacted by COVID-19 pandemic. Quarantine rules across the country are creating real challenges to some research projects, and slowing some of them down. Until such time that we are confident projects can move forward quickly and meet the rigorous milestones we require of our grant recipients, we are delaying the next round of research applications we will invite.

The crisis is also impacting our revenue. However, we remain committed to continuing to support the over 20,000 people with ALS and their families we serve throughout the country, and the over 170 research projects we are funding around the world. We also have several exciting research projects that are still under review that we think can proceed under current conditions. We look forward to announcing these new projects in the coming weeks. We will issue calls for research applications as soon as we think it wise to do so.

For Current Grantees:

The ALS Association provides milestone-based payments on current grants. If your organization is unable to complete and submit financial and research progress reports by their deadlines due to COVID-19 related issues, please contact our research department at We will ask you to provide a brief description for the delay and an estimated timeline for submission of materials. We will accept late reports but grant payments will be delayed until the reports are submitted and accepted.

Even though The Association staff is working remotely due to COVID-19, we are able to review progress reports and process payments. We currently have more than 170 active projects across the world and are monitoring their progress. We will meet our financial commitments to these projects, if the awardees are able to achieve their milestones.

If your institution or laboratory has closed due to COVID-19 and you or your staff are unable to work on research projects funded by The ALS Association, please contact our research department at as soon as you can. On a case by case basis, a no-cost extension (NCE) may be considered.

For Applicants:

The research staff at The ALS Association intends to roll our research RFAs in late April 2020. If there are any delays to this tentative timeline due to COVID-19, we will keep the community informed on the new timelines. The 2020 research RFAs will be posted on this web page:

The ALS Association plans to launch new RFAs by late April 2020 with pre-proposal submission deadlines in early June 2020. We are sensitive to COVID-19 and the effects on laboratories, research offices, and staff. We will keep an eye on the evolving situation and will extend the pre-proposal deadlines if needed.

As of today, The ALS Association is committed to spend $17M this year of new research and to maintain the pace of scientific discovery.

If you are experiencing delays on your project due to lab/office closures or shutdowns due to COVID-19, please complete and submit this form to

Principles for Urgent, Patient-Centered ALS Clinical Trials

The ALS Association is deeply committed to accelerating the development of novel ALS therapies and ensuring they are accessible to those who need them. The Association is announcing today its latest strategic action with the release of Principles for Urgent, Patient-Centered ALS Clinical Trials: a series of recommendations to clinical trial sponsors and regulatory bodies worldwide.

The Principles set out a clear framework for the design and conduct of ALS clinical trials that are efficient, impactful, and respectful. We view them as essential to both maximize the participation of people with ALS and their caregivers and to ensure every available tool is used to streamline drug development and regulatory-review processes.


ALS Research Toolkit

Everything we do supports our mission of finding treatments and a cure for ALS, which is why it is so critical to fund outstanding ALS research. We have the premier ALS research program in the world.

Our approach is simple and has led to some of the biggest research discoveries in the history of ALS. We fund the best, most promising research around the globe, while inspiring... and initiating innovative partnerships across all sectors – government, industry, academia, and other nonprofit organizations – while funding bright, young scientists to spur innovation.

Thanks to the donations raised during the ALS Ice Bucket Challenge, we are now spending three times more than on ALS research than before summer 2014. Click the button below to download the ALS Research Toolkit and learn more about our global research program.


Lawrence and Isabel Barnett
Drug Development Program


Our Lawrence and Isabel Barnett Drug Development Program allows us the freedom to strategically fund preclinical projects aimed at developing therapeutics for ALS that are product-driven. It is anticipated that the agents and/or data generated from these funded projects will lead to the advancement of new therapies for ALS.

This vital program is named in honor of Lawrence and Isabel Barnett, who contributed their time, talent and treasure to The ALS Association after a family friend was diagnosed with the disease. Their commitment to the fight against ALS helped enable tremendous progress in understanding the disease through groundbreaking research.

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Making a global impact

With The ALS Association’s ongoing support, my work in antisense technology, which was once thought of as innovative and risky, has led to clinical trials that could help people with ALS and other neurodegenerative diseases.

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Leading the way to a cure

Research Partners

The ALS Association is proud to forge partnerships and drive collaboration among individuals, non-profits, academic institutions, industry and government to accelerate the pace of ALS research.

Learn About Our Partnerships

Participate in clinical trials

Find up-to-date information on both federally and privately funded clinical studies focusing on ALS and motor neuron diseases.

Participate in a Clinical Trial

Funding global research

ALS Association-funded scientists are currently active in more than 11 countries around the world. We are grateful for our donors who make this global approach possible, getting us closer to our ultimate goal, a world without ALS.




View Research We Fund

Funding Opportunities

Throughout the year, The ALS Association offers multiple funding opportunities for scientists and clinicians made possible through support from our generous donors.


Call for Research Proposals

The ALS Association Research Program supports INNOVATIVE research of high scientific merit and relevance to ALS.

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You are part of the solution


Invest in The ALS Association’s research program to ensure that scientists around the globe have the resources they need to advance potential treatments to people like me who are living the disease.

Your gift will help The ALS Association support research to find treatments and a cure for ALS.

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For scientists looking for more information about grant opportunities and meetings, contact

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